The Perry Bible Fellowship: The Trial of Colonel Sweeto and Other Stories by Nicholas Gurewitch (2007). Even though there hasn't been much updating over the past several years, The Perry Bible Fellowship is still one of my favorite sites on the internet, and I was so happy to see its wonder captured in hard-cover book form.
Gurewitch published The Perry Bible Fellowship's amazing comics in various newspapers in the mid-2000s. I didn't find out about it until a few years ago when I quickly devoured the comics he has up on the PBF web site, linked above. If you haven't experienced them, spend a few minutes diving into the horrible wonder (like this, or this, or this).
The full-color book is nicely produced and contains a bunch of comics from the site mixed in with at least some that I had never seen before. At the end are some annotated outtakes and extras that provide a little insight into Gurewitch's comic-making system. The three-panel format is a perfect constraint for the rough chuckles in these tiny, harsh, universes.
You should probably just read all of these and then check out the book. Click here for a random one!